Publish Time: 2025-07-14 Origin: Site
2-Hydroxyethyl Methacrylate (2-HEMA), with CAS No. 868-77-9, is a colorless, transparent liquid with a faint odor, well-known for its excellent hydrophilic properties and reactivity. Used primarily as a monomer and intermediate in various polymer applications, this chemical compound plays a pivotal role across industries—from medical to industrial coatings, adhesives, contact lenses, and more. In this article, we will explore the diverse uses of 2-hydroxyethyl methacrylate, its benefits, technical specifications, and commonly asked questions related to its applications.
2-Hydroxyethyl Methacrylate (2-HEMA) is an ester of methacrylic acid and ethylene glycol. As a reactive monomer, it can undergo polymerization easily, making it suitable for synthesizing hydrogels and copolymers. The key attributes of 2-HEMA include:
Molecular Formula: C6H10O3
Molecular Weight: 130.14 g/mol
Appearance: Colorless to slightly yellow transparent liquid
Boiling Point: 95–96 °C (at 1.5 mmHg)
Purity: ≥ 98%
Acid Value: ≤ 0.5 mg KOH/g
Inhibitor (MEHQ): 200±50 ppm
Moisture Content: ≤ 0.3%
These properties make 2-HEMA extremely versatile. The hydroxyl group in the structure contributes to its hydrophilic nature, enabling it to interact with water—a valuable trait in biomedical materials.
Perhaps one of the most well-known applications of 2-hydroxyethyl methacrylate is in the production of soft contact lenses. The hydrophilic polymer formed from this monomer can absorb large amounts of water, resulting in a flexible, soft gel that is highly comfortable for extended eye wear.
When polymerized, 2-HEMA forms hydrogels with high oxygen permeability—essential for maintaining corneal health during lens use. Additionally, it is easily modified with other co-monomers to enhance properties such as tear resistance and oxygen transmissibility.
2-HEMA is a key ingredient in dental restorative materials, particularly in light-cured composite resins and adhesives. Its hydrophilic nature allows it to penetrate dentin and enamel surfaces for better adhesion. Furthermore, in orthopedic surgery, it is used in the formulation of bone cements for joint prostheses. These applications rely heavily on its compatibility with human tissue and excellent polymerization behavior.
Due to its polymerizing ability, 2-hydroxyethyl methacrylate is extensively used in adhesives and sealant formulations. In these applications, it enhances:
Bond strength between substrates
Flexibility and durability of the final bond
Water resistance, particularly in construction and automotive applications
The compound's hydroxyl group improves adhesion to a variety of surfaces, including metal, plastic, wood, and glass.
In the coatings industry, 2-HEMA is widely used as a functional monomer to improve the hydrophilicity, adhesion, and film-forming properties of water-based paints and varnishes. It enhances:
Dispersibility of pigments
UV resistance
Weather resistance of exterior coatings
Its performance as a reactive diluent also reduces viscosity in high-solid systems, allowing for improved application without sacrificing mechanical properties.
In polymer chemistry, 2-hydroxyethyl methacrylate is often used to synthesize smart hydrogels that respond to stimuli such as pH, temperature, or light. These hydrogels are critical for applications in:
Drug delivery systems
Tissue engineering scaffolds
Controlled release systems
Its ability to copolymerize with acrylates, methacrylates, and vinyl monomers makes it ideal for customizing performance properties.
Another rapidly growing application area for 2-HEMA is in UV-curable systems, including 3D printing resins. Its reactive double bond enables fast curing under UV light, making it suitable for:
Stereolithography (SLA)
Dental 3D printing materials
High-resolution printing applications
It ensures quick hardening, fine detail reproduction, and excellent mechanical properties after curing.
To aid professionals in selecting the appropriate product for their applications, here's a breakdown of the typical parameters of 2-Hydroxyethyl Methacrylate:
| Property | Specification |
|---|---|
| Appearance | Colorless to light yellow liquid |
| Assay (Purity) | ≥ 98% |
| Inhibitor Content (MEHQ) | 200 ± 50 ppm |
| Acid Value | ≤ 0.5 mg KOH/g |
| Moisture Content | ≤ 0.3% |
| Refractive Index (20°C) | 1.4510 – 1.4530 |
| Specific Gravity | 1.073 – 1.083 |
| Boiling Point | 95–96°C at 1.5 mmHg |
| CAS Number | 868-77-9 |
These parameters ensure the product's stability, reactivity, and suitability for various industrial and medical-grade applications.
When handled correctly, 2-HEMA is considered safe for industrial and medical applications. However, in its monomeric form, it can be an irritant to the skin, eyes, and respiratory system. Appropriate personal protective equipment (PPE) should always be worn. Once polymerized, such as in contact lenses or dental fillings, it becomes biocompatible and non-toxic.
To maintain product integrity, 2-HEMA should be:
Stored in cool, dry, and well-ventilated areas
Kept away from heat sources and direct sunlight
Stabilized with MEHQ inhibitor to prevent premature polymerization
Sealed tightly in containers to prevent moisture uptake
Proper storage is essential to preserve its monomer activity and prevent unwanted reactions.
Yes, 2-HEMA is highly compatible with a wide range of monomers such as MMA (methyl methacrylate), BA (butyl acrylate), and acrylic acid. This allows formulators to develop tailor-made polymers for specific performance requirements—be it mechanical strength, transparency, water absorption, or biocompatibility.
In summary, 2-hydroxyethyl methacrylate is a versatile monomer that bridges the gap between industrial materials science and biomedical innovation. Its unique structure allows for strong reactivity, excellent water compatibility, and wide-ranging polymer applications. Whether you're in the business of creating advanced contact lenses, medical adhesives, or high-performance coatings, 2-HEMA offers unmatched functionality and adaptability.
As industries increasingly demand safer, smarter, and more efficient materials, 2-HEMA continues to evolve as a cornerstone of modern polymer chemistry. Its enduring relevance across sectors underscores not only its chemical value but also its potential in shaping the next generation of high-performance materials.