Triethyl orthopropionate
【Chemical Name】 Triethyl orthopropionate
【Synonym】 1,1,1-TRIETHOXYPROPANE;TEOP;ORTHOPROPIONIC ACID TRIETHYL ESTER;Ethyl orthopropinate;ETHYL ORTHOPROPIONATE;Triethyl orthopropionate≥ 99% (GC);Triethyl orthopropiote;1,1,1-triethoxy-propan
【CAS No】115-80-0
【Molecular Formula】 C9H20O3
【Molecular Weight】176.25
【Properties】 Melting point 284 ° C Boiling point 155-160 ° C (lit.) Density 0.876 g/mL at 25 ° C (lit.) Refractive index n20/D 1.402 (lit.)
【Packing】200Kg/drum
【Usage】
1. Organic synthesis for the production of dyes, drugs, and film sensitizers
2. Organic synthesis, dye industry, pharmaceutical industry, and film sensitizer. Mainly used for the synthesis of halogenated betamethasone propionate, chloropetamethasone propionate, propyl Ubetaxel, and acyclovir.
【Introduction】
Triethyl orthotropionate is an important organic synthetic intermediate widely used in various fields, including the dye industry, pharmaceutical industry, and film sensitizer. The following are its main uses and applications:
1. Organic synthesis
Triethyl orthopropionate is commonly used in organic synthesis, especially in the construction of new carbon carbon bonds. For example, it can generate new C-C bonds through Claisen rearrangement reaction. In addition, it can also be used to synthesize other organic compounds, such as reacting with pyrrole and chloroacetic acid to produce 1,1,1- [tris (pyrrole-2-yl)] propane.
2. Pharmaceutical industry
Triethyl orthopropionate is an important intermediate in the synthesis of various drugs. It is mainly used for synthesizing the following drugs:
-Halobetasol Propionate
-Clobetasol Propionate
-Propyl Ubetaxel
-Aclometasone.
In addition, it is also a synthetic material for the antimalarial drugs Chloroquine and Quinidine.
3. Dye industry
In the dye industry, Triethyl orthopropionate is used as an intermediate for synthesizing dyes. It can generate other useful compounds through ester exchange reactions, which can be used to produce various dyes.
4. Film sensitizer
Triethyl orthopropionate is also used as a film sensitizer, which can increase the sensitivity of the film to light, thereby improving the imaging effect.
summarize
Triethyl orthopropionate is a multifunctional organic compound widely used in fields such as organic synthesis, pharmaceutical industry, dye industry, and film sensitizer. Its importance in drug synthesis is particularly prominent, as it serves as an intermediate for various key drugs.