Chemical Name: Palmitoyl Pentapeptide-4
Chemical Synonyms: L-Serine,N2-(1-oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-;Matrixyl(PAL-KTTKS);N2-(1-Oxohexadecyl)-L-lysyl-L-threonyl-L-threonyl-L-lysyl-L-Chemicalbookserine;PalmitoylPentapeptidePAL-Lys-Thr-Thr-Lys-Ser;Matrixyl(PalmitoylPentapeptide);Matrixyl,Palmitoylpentapeptide-4;Matrixylacetate,>=95%;Pla-KTTKS
CAS No.: 214047-00-4
Molecular Formula: C39H75N7O10
Molecular Weight: 802.06
Palmitoyl Pentapeptide-4 (CAS 214047-00-4), widely known as Matrixyl, is a cosmetic signal peptide that stimulates collagen synthesis and helps reduce the appearance of wrinkles. Its KTTKS sequence is a naturally occurring fragment of procollagen I C-propeptide that signals fibroblasts to produce Collagen I, III, and Fibronectin . The palmitoyl group enhances penetration through the stratum corneum. With assay ≥99% and cosmetic-grade quality, it is suitable for anti-aging serums, creams, and firming formulations.
Parameter | Specification |
|---|---|
Product Name | Palmitoyl Pentapeptide-4 |
Synonyms | Matrixyl; Pal-KTTKS; Palmitoyl Pentapeptide |
CAS Number | 214047-00-4 |
Molecular Formula | C₃₉H₇₅N₇O₁₀ |
Molecular Weight | 802.06 g/mol |
Assay / Purity | ≥99% (HPLC) |
Appearance | White to off-white powder |
Grade | Cosmetic Grade |
Sequence | Pal-Lys-Thr-Thr-Lys-Ser-OH |
Storage | 2–8°C, protected from light and moisture |
Anti-Wrinkle Serums & Creams: Reduces wrinkle depth and skin roughness through collagen stimulation .
Firming & Anti-Aging Moisturizers: Supports skin firmness and elasticity in daily care products.
Premium Anti-Aging Concentrates: Suitable for ampoules and high-performance treatment formulations.
Collagen-Boosting Formulations: Ideal for products targeting mature or photoaged skin.
Clinically Validated Mechanism: A 12-week split-face randomized controlled trial demonstrated significant improvements in wrinkle depth and skin roughness versus vehicle control .
Well-Established Reference Peptide: Matrixyl is one of the most extensively studied cosmetic signal peptides, introduced by Sederma in 2000 and widely used as a benchmark in cosmetic research .
Non-Irritating Alternative: Provides anti-aging efficacy without the irritation associated with retinol-based actives .
Full Documentation: COA and MSDS available upon request for regulatory and formulation compliance.
Standard Packaging: 1 g / 10 g / 100 g / 1 kg in sealed vials or aluminum foil bags, or customized packaging upon request.
Storage Conditions: Store at 2–8°C, protected from light and moisture. Lyophilized powder is stable under proper storage.
Shelf Life: 24 months under proper storage conditions.