Tetrakis(triphenylphosphine)palladium
【Chemical Name】 Tetrakis(triphenylphosphine)palladium
【Synonym】 (beta-4)-palladiu;Tetrakis(triphenylphosphine)palladium(0),99.8%(metalsbasis),Pd9%min;Tetrakis(triphenylphosphine)palladium(0)StorerefrigeratedProtectfromlight;Tetrakis(triphenylpChemicalbookhosphine)p;Tetrakis(triphenylphosphine)palladiu;Tetrakis(triphenylphosphine)Palladium(0),Pd(PPh3)4;Terakis(triphenylphosphine)palladi;Tetrakis(triphenylphosphine)palladiuM(0),99.8%
【CAS No】14221-01-3
【Molecular Formula】 C72H60P4Pd
【Molecular Weight】1155.561844
【Properties】 Melting point 103-107 ° C, vapor pressure 0Pa at 25 ° C, storage conditions 2-8 ° C, solubility soluble in chloroform (small amount), ethyl acetate (small amount), methanol (small amount), finely shaped powder or plate color, bright yellow to khaki color
【Packing】500g/drum
【Usage】 Tetratriphenylphosphine palladium is used as a catalyst in coupling reactions such as Suzuki, Kumada, Negishi, etc; It can be used as a specialized catalyst for the synthesis of pharmaceuticals and pesticides (such as methylamine avermectin benzoate), and is widely used in important isomerization reactions as a lateral coupling reaction catalyst.
【Introduction】
Tetrakis (triphenylphosphine) palladium, abbreviated as Pd (PPh3) 4, is an important organic synthesis catalyst widely used in various coupling reactions, including Suzuki, Kumada, and Negishi coupling reactions. These reactions play an important role in the synthesis of drugs and pesticides, such as emamectin benzoate.
In the Suzuki coupling reaction, Pd (PPh3) 4 acts as a catalyst to promote the cross coupling reaction between organic boronic acid and halogenated hydrocarbons, forming carbon carbon bonds. This reaction typically occurs at room temperature and has a wide range of substrate applicability, including aryl, alkyl, vinyl, and alkynyl halides.
The Kumada coupling reaction is a cross coupling reaction between Grignard reagent and halogenated hydrocarbons catalyzed by nickel or palladium. The advantage of this reaction is that it can directly use Grignard reagents, avoiding the additional step of converting Grignard reagents into zinc compounds, and is suitable for synthesizing asymmetric aromatic compounds.
The Negishi coupling reaction is a cross coupling reaction between organic zinc reagents and halogenated hydrocarbons catalyzed by nickel or palladium. This reaction has a wide range of substrate applications, not limited to the formation of aromatic groups, but can also be used to synthesize various compounds containing carbon carbon bonds.
Tetrakis (triphenylphosphine) palladium also faces some challenges in the synthesis process, such as the production of difficult to separate by-products, solvent and catalyst recovery issues, etc. To address these issues, researchers are developing new synthetic methods, such as encapsulating catalysts in hollow porous nanomaterials to improve their stability and recyclability.
In addition, tetrakis (triphenylphosphine) palladium is sensitive to light and air and needs to be stored in an inert gas away from light. In practical applications, it can be operated in air for a short period of time, but it is best to operate under nitrogen or argon protection. The importance of this catalyst in organic synthesis is self-evident, as it plays a crucial role in the synthesis of various drugs and pesticides.