【Chemical Name】 N,N-Dimethylpropionamide
【Synonym】 N,N-Dimethylpropionamide98%;N,N-Dimethylpropionamide 98%;DIMETHYLPROPIONAMIDE, N,N'-;Dimethylamide of propionic acid;dimethylamideofpropionicacid;n,n-dimethyl-propanamid;N,N-Dimethylpropanamide;N,N-dimethyl-Propanamide
【CAS No】 758-96-3
【Molecular Formula】 C5H11NO
【Molecular Weight】 101.15
【Properties】 Melting point-45 °C (lit.)Boiling point174-175 °C (lit.)
Density0.92 g/mL at 25 °C (lit.)Refractive index1.438-1.442
【Specification】≥99
【Packing】200kg/drum
【Usage】 N,N-Dimethylpropionamide is used as an intermediate in organic synthesis and pharmaceuticals.
【Introduction】
The core value of DMPA lies in its application as a key intermediate and efficient reaction solvent in organic synthesis and the pharmaceutical industry:
1. Organic Synthesis Intermediate:
• Synthesis of amide compounds: DMPA itself is a derivative of propionamide and can serve as a basic raw material for constructing more complex amide molecules. For example, its amide group can participate in condensation reactions or act as a precursor of acylating agents.
• Synthesis of nitrogen-containing heterocyclic compounds: In the construction of nitrogen-containing heterocyclic structures such as pyrrolidine and piperidine, DMPA or its derivatives can function as effective synthetic building blocks or participate in cyclization reactions.
• Synthesis of pharmaceutically active molecules: Many pharmaceutically active molecules with biological activity (such as certain antibiotics, antiviral drugs, central nervous system drugs, etc.) utilize DMPA or its derivatives as structural units in key intermediate steps during their synthetic routes. The amide bond and propyl chain in its molecule are often designed as part of the pharmacophore or as linking groups.
2. Pharmaceutical Industry:
• Pharmaceutical synthesis intermediate: DMPA is an important intermediate in the synthesis of various active pharmaceutical ingredients (APIs). In specific synthetic routes, it may participate in:
• Formation of amide bonds in the core skeleton of drug molecules.
• Acting as a precursor for introducing specific functional groups (such as propionamide groups). Participating in functional group transformation reactions involving amide groups (such as reduction, alkylation, etc.).
• Reaction solvent: Due to its high boiling point, good solubility, and relative inertness (stable to strong bases), DMPA is often chosen as a solvent for some organic reactions, especially when higher reaction temperatures or dissolution of special substrates are required, such as:
• Metal-catalyzed coupling reactions (e.g., Heck, Suzuki reactions). *Reactions involving strong bases (e.g., Dieckmann condensation).
• Polymer polymerization reactions.
• Reactions requiring anhydrous and oxygen-free conditions.
• Drug crystallization and purification: Sometimes used as a recrystallization solvent or a component of the mobile phase in chromatographic separation.
3. Other Applications:
• Polymer industry: Used as a solvent or monomer in polymerization reactions.
• Electronic chemicals: Used in photoresists, electronic-grade cleaning fluids, etc.
• Extraction solvent:Used in separation and purification processes.