Chemical Name: Laurocapram
Chemical Synonyms: Azone; 1-Dodecylazacycloheptan-2-one; N-Dodecyl-ε-caprolactam
CAS No.: 59227-89-3
Molecular Formula: C₁₈H₃₅NO
Molecular Weight: 281.48 g/mol
Laurocapram (CAS 59227-89-3), commonly known as Azone, is a widely used transdermal penetration enhancer that improves the absorption of both hydrophilic and lipophilic active ingredients through the skin. It works by disrupting the ordered lipid bilayer structure in the stratum corneum, temporarily increasing intercellular lipid fluidity and reducing skin barrier resistance . With assay ≥99% (pharma grade) / ≥98% (cosmetic grade), it is suitable for topical pharmaceutical formulations, cosmetic actives delivery, and agrochemical adjuvants.
Parameter | Specification |
|---|---|
Product Name | Laurocapram |
Synonyms | Azone; 1-Dodecylazacycloheptan-2-one; N-Dodecyl-ε-caprolactam |
CAS Number | 59227-89-3 |
Molecular Formula | C₁₈H₃₅NO |
Molecular Weight | 281.48 g/mol |
Assay / Purity | ≥99% (Pharma Grade) / ≥98% (Cosmetic Grade) |
Appearance | Colorless to pale yellow clear oily liquid |
Solubility | Soluble in ethanol, ether, oils; insoluble in water |
Refractive Index | 1.469–1.474 (20°C) |
Storage | Cool, dark place, protect from light and heat |
Pharmaceutical Transdermal Delivery: Enhances percutaneous absorption of drugs in creams, gels, and patches. Typical usage: 1–3% (up to 5%) .
Cosmetic Actives Delivery: Improves penetration of whitening, anti-aging, and hydrating ingredients. Typical usage: 0.1–2% .
Agrochemical Enhancement: Increases leaf-surface penetration of insecticides and fungicides, improving efficacy and duration .
Dyeing & Leather Processing: Used as a color-fixing accelerator in textile and leather applications .
Dual-Action Penetration Enhancement: Effective for both water-soluble and oil-soluble active ingredients, with documented penetration rate improvements of 5–8 times .
Low Irritation Profile: Widely described as non-toxic and non-irritating at recommended usage levels .
Multiple Grades Available: Pharma grade and cosmetic grade to match your application and regulatory requirements.
Full Documentation: COA and MSDS available upon request.
Environmental Hazard: Classified as H413 (May cause long-lasting harmful effects to aquatic life). Avoid release to the environment .
Handling: Use in a well-ventilated area. Avoid contact with eyes and prolonged skin contact.
Storage: Store in a tightly closed container, protected from light and heat. Recommended storage below 15°C in a cool, dark place .
Standard Packaging: 1 kg / 5 kg / 25 kg in plastic drums or amber glass containers, or customized packaging upon request.
Storage Conditions: Store in a tightly closed container in a cool, dark place, protected from light and heat. Inert gas recommended for long-term storage.
Shelf Life: 24 months under proper storage conditions.