Chemical Name: Kojic Acid Dipalmitate
Chemical Synonyms: Kojic Dipalmitate; KAD; 2-Palmitoyloxymethyl-5-palmitoyloxy-pyrone
CAS No.: 79725-98-7
Molecular Formula: C₃₈H₆₆O₆
Molecular Weight: 618.93 g/mol
Kojic Acid Dipalmitate (CAS 79725-98-7), also known as Kojic Dipalmitate or KAD, is a lipid-soluble ester derivative of kojic acid designed to overcome the stability limitations of conventional kojic acid. By esterifying both hydroxyl groups with palmitic acid, it eliminates the light, heat, and metal-ion instability that causes kojic acid to discolor, while preserving its tyrosinase-inhibiting activity for melanin reduction . As an oil-soluble active, it is more readily absorbed by the skin and is compatible with a wide range of cosmetic ingredients, making it suitable for whitening creams, emulsions, and serums.
Parameter | Specification |
|---|---|
Product Name | Kojic Acid Dipalmitate |
Synonyms | Kojic Dipalmitate; KAD; 2-Palmitoyloxymethyl-5-palmitoyloxy-pyrone |
CAS Number | 79725-98-7 |
Molecular Formula | C₃₈H₆₆O₆ |
Molecular Weight | 618.93 g/mol |
Assay / Purity | ≥99% (HPLC) |
Appearance | White to off-white crystalline powder |
Melting Point | 92–96 °C |
Solubility | Oil-soluble; soluble in mineral oil, esters, and hot ethanol; insoluble in water |
pH Stability | Stable across pH 3–10 |
Grade | Cosmetic Grade |
Storage | Cool, dry place, protected from light and moisture |
Skin Whitening & Brightening: Inhibits tyrosinase activity to reduce melanin formation, suitable for products targeting hyperpigmentation, melasma, freckles, and age spots .
Anti-Aging Formulations: Combines whitening with antioxidant benefits for comprehensive age-defense products.
Sun Care & After-Sun: Stable under heat, suitable for post-sun repair and skin-tone evening formulations .
Oil-Phase Incorporation: Dissolve in the oil phase at temperatures below 70°C to ensure complete dissolution without degradation .
Superior Stability vs. Kojic Acid: Esterification of both hydroxyl groups eliminates the light, heat, and metal-ion discoloration issues of kojic acid, ensuring color stability in finished products .
Excellent Compatibility: The absence of free hydroxyl groups prevents hydrogen bonding with preservatives and sunscreen actives, allowing trouble-free combination with other cosmetic ingredients .
Enhanced Skin Absorption: Oil-soluble nature enables better penetration and absorption compared to water-soluble kojic acid .
Clinically Studied: Kojic acid dipalmitate has been evaluated in dermatological research for hyperpigmentation treatment, demonstrating tyrosinase inhibition and skin-whitening effects .
Full Documentation: COA and MSDS available upon request.
Recommended Usage: 1–5% (typically 3–5% in whitening products) .
Incorporation Method: Dissolve in the oil phase (mineral oil, isopropyl palmitate, or isopropyl myristate) by heating to approximately 68°C. Add to the oil phase before emulsification .
Processing Caution: Do not exceed 70°C during incorporation to avoid degradation .
pH Range: Formulate within pH 3–10 (optimal 4–7) for maximum stability .
Standard Packaging: 1 kg / 5 kg / 25 kg in aluminum foil bags or fiber drums, or customized packaging upon request .
Storage Conditions: Store in a tightly closed container in a cool, dry place, protected from light and moisture.
Shelf Life: 24–36 months under proper storage conditions .