Guanidine Thiocyanate
Guanidine Thiocyanate (GTC) is a strong chaotropic salt widely used in molecular biology. It is a powerful protein denaturant and an essential reagent for the isolation and purification of intact nucleic acids (DNA and RNA) from various biological samples. Its ability to inactivate nucleases (such as RNases) while keeping nucleic acids soluble makes it a cornerstone of many modern molecular biology protocols.
| Item | Specification |
|---|---|
| CAS No. | 593-84-0 |
| Molecular Formula | CH₆N₄·HSCN or C₂H₆N₄S |
| Appearance | White to off-white crystalline powder |
| Purity | ≥99% |
| Molecular Weight | 118.16 g/mol |
| Solubility | Highly soluble in water and ethanol |
| Storage | Store at room temperature in a dry place. |
Guanidine Thiocyanate is a critical component in numerous research and industrial processes:
RNA & DNA Isolation: It is the key active ingredient in many single-step RNA extraction methods (e.g., the acid guanidinium thiocyanate-phenol-chloroform method). It effectively lyses cells, denatures proteins and nucleases, and creates conditions where RNA remains stable and in solution.
Protein Denaturation: Used as a strong chaotropic agent to solubilize and denature proteins for downstream analysis in biochemistry.
Biochemical Research: Serves as a versatile reagent in various molecular biology applications requiring the disruption of cellular structures and inactivation of enzymes.
Industrial Applications: Functions as a chemical intermediate and in other specialized industrial processes.
Note: For research use only. Not for diagnostic or therapeutic use.
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As a reliable manufacturer, we ensure a stable annual production capacity of 1000 tons of high-purity Guanidine Thiocyanate. We also offer a comprehensive range of related guanidine derivatives, including Guanidine Hydrochloride (liquid and solid forms) and Guanidine Carbonate.
Our commitment is to provide consistent quality, reliable supply, and expert support for your research and industrial needs. Partner with us for a seamless supply of this essential biochemical reagent.