Trimethylsulfoxonium iodide
【Chemical Name】Trimethylsulfoxonium iodide
【Synonym】 rimethylsulfoxoniumiodide;Trimethylsulfoxoniumiodide,>=99%;Trimethyl(oxo)-sulfanyliumiodide;Trimethylsulfoxideiodide;TrimethChemicalbookylsulfoxoniumiodide≥99%(Titration);sulfonium,trimethyl-,iodide,oxide;Sulfoxonium,trimethyl-,iodide;trimethyl-sulfoxoniuiodide
【CAS No】1774-47-6
【Molecular Formula】 C3H9IOS
【Molecular Weight】220.07
【Properties】 Melting point -78 ° C, boiling point 128-131 ° C (20 mm Hg), density 0.841 g/mL (25 ° C), vapor pressure 30 Pa (20 ° C)
【Packing】165Kg/drum or package as your requirements.
【Usage】
Trimethylsulfoxonium iodide is a white to pale yellow crystalline substance that is soluble in water and dimethyl sulfoxide, and slightly soluble in methanol.
1. It is used to synthesize methylene transfer reagents for the preparation of epoxides. 2. It is mainly used in the synthesis of fluconazole.
3. Strong base treatment can generate iodonium salts, which can undergo addition reactions with the carbonyl groups of ketones and aldehydes to form epoxides; they can also preferentially add to the double bond of α,β-unsaturated esters to form cyclopropanecarboxylates.
【Introduction】
# Trimethylsulfoxonium Iodide Product Detail
## Product Description
Trimethylsulfoxonium Iodide (CAS No.: 1774-47-6) is a white to pale yellow crystalline powder that is soluble in water and dimethyl sulfoxide, and slightly soluble in methanol. It is a sulfoxonium salt used in various chemical reactions as a methylene-transfer reagent.
## Product Advantages
- **Efficient Catalytic Properties**: It is highly effective in promoting the formation of epoxides through methylene transfer reactions, ensuring high yields and selectivity in organic synthesis.
- **Versatile Reactivity**: Besides epoxide synthesis, it is crucial in the production of fluconazole, showcasing its adaptability in pharmaceutical manufacturing.
- **Controlled Reaction Conditions**: Allows for precise reaction control when generating iodonium salts under strong base conditions, facilitating the synthesis of complex molecules like cyclopropanecarboxylates.
- **Stability and Safety**: Compared to other reagents, it offers better stability and safer handling conditions, reducing risks during laboratory and industrial applications.
## Product Characteristics
- **Physical State**: White to pale yellow crystalline powder.
- **Solubility**: Soluble in water (50 mg/mL) and dimethyl sulfoxide, slightly soluble in methanol.
- **Melting Point**: 208-212 °C (dec.) (lit.)
- **pH Value**: 4.8-6.0 (50g/l, 25℃)
- **Sensitivity**: Light sensitive; should be protected from light during storage and handling.
- **Molecular Weight**: 220.07 g/mol.
## Product Applications
- **Pharmaceutical Industry**: Key intermediate in the synthesis of fluconazole, an antifungal medication.
- **Organic Synthesis**: Used to prepare methylene transfer reagents for epoxide production, which are vital in fine chemicals and materials science.
- **Specialty Chemicals**: Facilitates the formation of cyclopropanecarboxylates by adding to α,β-unsaturated esters, useful in agrochemicals and polymers.
## Product Transportation
Trimethylsulfoxonium Iodide should be transported in sealed, light-resistant containers under cool and dry conditions. It is essential to comply with regulations for hazardous chemical transportation and ensure proper labeling to indicate light sensitivity and chemical hazards.
## Product Specifications
- **Purity**: ≥98%
- **Moisture Content**: ≤0.5%
- **Particle Size**: Fine powder, passing through a specified mesh size.
- **Packaging**: Available in various sizes, including 25g, 100g, 500g, and 1kg packages, with options for bulk quantities.
## User Reviews
- "This reagent has revolutionized our epoxide synthesis process. The high purity ensures consistent reaction outcomes and minimizes by-products." - ChemSynth Laboratories
- "As a key intermediate for fluconazole, its reliability and quality have significantly improved our pharmaceutical production efficiency and product purity." - PharmaCore Industries
- "The controlled reactivity of Trimethylsulfoxonium Iodide allows us to achieve precise synthesis of complex molecules, making it an indispensable tool in our organic chemistry research." - BioChem Research Institute