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Chemical Name: Potassium 2-Hydroxy-4-Methoxybenzoate
Chemical Synonyms: Potassium Methoxysalicylate;Potassium 4-Methoxysalicylate;4MSK
CAS No.: 152312-71-5
Molecular Formula: C8H7KO4
Molecular Weight: 206.24
Potassium 2-Hydroxy-4-Methoxybenzoate (CAS 152312-71-5), commonly known as 4MSK (Potassium 4-Methoxysalicylate), is a high-purity cosmetic active ingredient widely used in skin-lightening and brightening formulations. It works by suppressing melanin production and promoting normal keratinocyte differentiation, offering a dual-action mechanism that distinguishes it from conventional tyrosinase inhibitors. With assay ≥99% and cosmetic-grade quality, it is suitable for serums, essences, creams, and lotions.
Parameter | Specification |
|---|---|
Product Name | Potassium 2-Hydroxy-4-Methoxybenzoate |
Synonyms | 4MSK; Potassium 4-Methoxysalicylate; Potassium Methoxysalicylate |
CAS Number | 152312-71-5 |
Molecular Formula | C₈H₇KO₄ |
Molecular Weight | 206.24 g/mol |
Assay / Purity | ≥99% (HPLC) |
Appearance | White to off-white crystalline powder |
Grade | Cosmetic Grade |
Melting Point | ≥235 °C |
Storage | Cool, dry place, protected from light and moisture |
Skin Lightening & Brightening: Reduces melanin content and improves skin lightness in both pigmented and non-pigmented areas.
Hyperpigmentation Care: Suitable for formulations targeting dark spots, uneven skin tone, and post-inflammatory hyperpigmentation.
Keratinocyte Normalization: Promotes normal keratinocyte differentiation without the irritation associated with free salicylic acid.
Cosmetic Formulations: Recommended usage level up to 3% in serums, essences, creams, and lotions.
Dual-Action Mechanism: Suppresses melanin production while supporting normal keratinocyte differentiation, offering advantages over single-action whitening agents.
Cosmetic-Grade Purity: Assay ≥99% with controlled heavy metals and microbial limits, suitable for leave-on skincare products.
Clinically Supported: 4MSK has been evaluated in clinical studies demonstrating significant skin-lightening effects.
Full Documentation: COA and MSDS available upon request for regulatory and formulation compliance.
Standard Packaging: 1 kg / 5 kg / 25 kg in aluminum foil bags or fiber drums, or customized packaging upon request.
Storage Conditions: Store in a tightly closed container in a cool, dry place, protected from light and moisture.
Shelf Life: 24 months under proper storage conditions.






