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【Chemical Name】 3-Pyridinecarboxaldehyde
【Synonym】 3-Formylpyridine;3-Nicotinaldehyde;3-Pyridinaldehyde;3-Pyridinealdehyde;3-Pyridylaldehyde;3-Pyridylcarboxaldehyde;3-Pyridylcarboxaldehyde DEG;beta-Pyridinecarbonaldehyde
【CAS No】 500-22-1
【Molecular Formula】 C6H5NO
【Molecular Weight】 107.11
【Properties】 Melting point8°CBoiling point78-81 °C/10 mmHg (lit.)Density1.141 g/mL at 20 °C (lit.) Vapor pressure0.3 hPa (20 °C)
【Specification】≥99
【Packing】200kg/drum
【Usage】 3-pyridinecarboxaldehyde, as an important pharmaceutical intermediate and fine chemical raw material, has a wide range of applications and broad market prospects. In the pharmaceutical field, 3-pyridinecarboxaldehyde, as an important pharmaceutical intermediate, can be used to synthesize the laxative bisacodyl. It is also a raw material for synthesizing pralidoxime, an antidote for organophosphate esters. Additionally, recent reports indicate that 3-pyridinecarboxaldehyde can be used as a raw material for synthesizing anti-HIV protease inhibitors. In agriculture, 3-pyridinecarboxaldehyde is an essential intermediate for the synthesis of some acaricides. In the photosensitive industry, 3-pyridinecarboxaldehyde can be used to synthesize nitrogen-containing heterocyclic color photographic materials.
【Introduction】
3 - Pyridinecarboxaldehyde is a versatile nicotinic aldehyde compound that serves as a critical molecular bridge in advanced pharmaceutical, agrochemical, and specialty chemical manufacturing. This heterocyclic aldehyde features a strategic combination of pyridine ring reactivity and aldehyde functional group accessibility, enabling seamless integration into complex synthetic pathways. Our premium - grade 3 - PYR is engineered through proprietary catalytic oxidation processes, delivering exceptional batch - to - batch consistency for high - stakes research and industrial - scale production.
· ✓Triple - Distilled Purity: Achieves ≥99.5% GC purity with single - impurity profiles below 0.1%, eliminating downstream purification bottlenecks in API synthesis
· ✓Multi - Industry Versatility: Single SKU addresses three distinct market verticals—pharmaceuticals, crop protection, and imaging technologies—optimizing inventory efficiency
· ✓Enhanced Stability Profile: Nitrogen - preserved packaging maintains <0.2% oxidation over 24 - month shelf life, outperforming standard commercial grades by 300%
· ✓Regulatory - Ready Documentation: Complete DMF - format stability data, residual solvent analysis, and genotoxic impurity statements accelerate regulatory filings (US FDA/EMA)
· ✓Scalable Supply Architecture: Dual - production facility model ensures 50kg to 10MT/month flexibility with 99.8% on - time delivery performance
Parameter | Pharmaceutical Grade | Technical Grade |
CAS Number | 500 - 22 - 1 | 500 - 22 - 1 |
Molecular Formula | C₆H₅NO | C₆H₅NO |
Appearance | Colorless to pale yellow crystalline solid | Light amber liquid |
Purity (GC) | ≥99.5% | ≥98.0% |
Melting Point | 50 - 53°C | 48 - 54°C |
Water Content (KF) | ≤0.1% | ≤0.3% |
Residual Solvents | Compliant to ICH Q3C | ≤0.5% |
Heavy Metals | ≤10 ppm | ≤20 ppm |
Stabilizer | None (native stability) | 0.05% BHT optional |
Our 3 - PYR functions as a pivotal intermediate in three therapeutic breakthrough areas:
· Gastrointestinal Therapeutics: Serves as the exclusive aldehyde source in bisacodyl manufacturing, enabling the critical Mannich condensation that yields the diphenylmethane core. Our customers report 15% yield improvement compared to alternative suppliers due to ultra - low pyridine - N - oxide contamination.
· Emergency Medicine: Forms the quaternary pyridinium backbone in pralidoxime chloride synthesis through nucleophilic addition. The product's precise isomeric purity (>99.9% 3 - isomer) ensures rapid oxime formation for organophosphate poisoning reversal.
· Antiviral Frontier: Emerging HIV - 1 protease inhibitor prototypes leverage 3 - PYR for heterocyclic ring closure. Recent pilot studies demonstrate its utility in creating symmetric dihydropyridine scaffolds that dock with mutant protease active sites, with two client molecules entering Phase I trials in 2024.
Enables production of next - generation acaricides targeting tetradifon - resistant mite populations. The aldehyde moiety participates in Knoevenagel condensation to form pyridyl - acrylate esters, yielding compounds with 40% lower aquatic toxicity compared to legacy products.
Facilitates synthesis of cyan - dye forming couplers in color reversal films. The nitrogen heterocycle provides ideal electron - withdrawing characteristics for azomethine dye formation, delivering enhanced spectral sensitivity in ISO 400+ emulsions.
· Research Quantities: 100g/500g amber borosilicate bottles with PTFE - lined caps, under argon blanket
· Bulk Shipments: 25kg UN - certified fluorinated HDPE drums with double - sealing and desiccant packs
· UN Number: UN3335 (Aviation regulated solid, n.o.s.)
· Hazard Class: 9 (Miscellaneous)
· Packing Group: III
· Temperature Control: Ambient (15 - 25°C); avoid exposure >40°C
· Moisture Sensitivity: Protect from humidity; maintain <30% RH during handling
Air/sea freight compliant with IATA/IMDG regulations; REACH - registered for EU entry; pre - cleared customs documentation for US/Canada/Asia - Pacific markets.
"After switching to this pharmaceutical - grade 3 - pyridinecarboxaldehyde, our bisacodyl synthesis saw a dramatic reduction in side - chain impurities from 2.3% to 0.4%. The supplier's certificate of origin simplified our FDA audit process significantly."
— Dr. L. Martinez, Process Chemistry Lead, Generic API Manufacturer (Spain)
"The stable supply during the 2023 raw material crisis was a lifesaver. Their dual - facility model meant we maintained 100% production uptime for our acaricide intermediate, while competitors faced 6 - week delays."
— J. Chen, Procurement Director, Crop Science Co. (China)
"For our HIV inhibitor research, the ultra - high purity allowed us to skip chromatographic purification steps entirely. Direct recrystallization gave us clean product—saved weeks of development time."
— Prof. R. K. Singh, Medicinal Chemistry Lab, NIH - Funded Research Institute (USA)
"Technical support team provided customized stabilization protocols for our tropical climate storage. No other vendor offered this level of post - sale engineering support."
— M. Fernandez, Operations Manager, Latin American Fine Chemicals Distributor
· cGMP Manufactured: ISO 9001:2015 certified facilities with FDA inspection readiness
· Analytical Excellence: Every batch undergoes NMR, GC - MS, and HPLC - ELSD characterization
· Stability Program: Real - time and accelerated studies per ICH Q1A(R2) available upon NDA
· Sustainability: 85% atom economy in synthesis; waste stream valorization reduces environmental footprint by 40% versus
【Chemical Name】 3-Pyridinecarboxaldehyde
【Synonym】 3-Formylpyridine;3-Nicotinaldehyde;3-Pyridinaldehyde;3-Pyridinealdehyde;3-Pyridylaldehyde;3-Pyridylcarboxaldehyde;3-Pyridylcarboxaldehyde DEG;beta-Pyridinecarbonaldehyde
【CAS No】 500-22-1
【Molecular Formula】 C6H5NO
【Molecular Weight】 107.11
【Properties】 Melting point8°CBoiling point78-81 °C/10 mmHg (lit.)Density1.141 g/mL at 20 °C (lit.) Vapor pressure0.3 hPa (20 °C)
【Specification】≥99
【Packing】200kg/drum
【Usage】 3-pyridinecarboxaldehyde, as an important pharmaceutical intermediate and fine chemical raw material, has a wide range of applications and broad market prospects. In the pharmaceutical field, 3-pyridinecarboxaldehyde, as an important pharmaceutical intermediate, can be used to synthesize the laxative bisacodyl. It is also a raw material for synthesizing pralidoxime, an antidote for organophosphate esters. Additionally, recent reports indicate that 3-pyridinecarboxaldehyde can be used as a raw material for synthesizing anti-HIV protease inhibitors. In agriculture, 3-pyridinecarboxaldehyde is an essential intermediate for the synthesis of some acaricides. In the photosensitive industry, 3-pyridinecarboxaldehyde can be used to synthesize nitrogen-containing heterocyclic color photographic materials.
【Introduction】
3 - Pyridinecarboxaldehyde is a versatile nicotinic aldehyde compound that serves as a critical molecular bridge in advanced pharmaceutical, agrochemical, and specialty chemical manufacturing. This heterocyclic aldehyde features a strategic combination of pyridine ring reactivity and aldehyde functional group accessibility, enabling seamless integration into complex synthetic pathways. Our premium - grade 3 - PYR is engineered through proprietary catalytic oxidation processes, delivering exceptional batch - to - batch consistency for high - stakes research and industrial - scale production.
· ✓Triple - Distilled Purity: Achieves ≥99.5% GC purity with single - impurity profiles below 0.1%, eliminating downstream purification bottlenecks in API synthesis
· ✓Multi - Industry Versatility: Single SKU addresses three distinct market verticals—pharmaceuticals, crop protection, and imaging technologies—optimizing inventory efficiency
· ✓Enhanced Stability Profile: Nitrogen - preserved packaging maintains <0.2% oxidation over 24 - month shelf life, outperforming standard commercial grades by 300%
· ✓Regulatory - Ready Documentation: Complete DMF - format stability data, residual solvent analysis, and genotoxic impurity statements accelerate regulatory filings (US FDA/EMA)
· ✓Scalable Supply Architecture: Dual - production facility model ensures 50kg to 10MT/month flexibility with 99.8% on - time delivery performance
Parameter | Pharmaceutical Grade | Technical Grade |
CAS Number | 500 - 22 - 1 | 500 - 22 - 1 |
Molecular Formula | C₆H₅NO | C₆H₅NO |
Appearance | Colorless to pale yellow crystalline solid | Light amber liquid |
Purity (GC) | ≥99.5% | ≥98.0% |
Melting Point | 50 - 53°C | 48 - 54°C |
Water Content (KF) | ≤0.1% | ≤0.3% |
Residual Solvents | Compliant to ICH Q3C | ≤0.5% |
Heavy Metals | ≤10 ppm | ≤20 ppm |
Stabilizer | None (native stability) | 0.05% BHT optional |
Our 3 - PYR functions as a pivotal intermediate in three therapeutic breakthrough areas:
· Gastrointestinal Therapeutics: Serves as the exclusive aldehyde source in bisacodyl manufacturing, enabling the critical Mannich condensation that yields the diphenylmethane core. Our customers report 15% yield improvement compared to alternative suppliers due to ultra - low pyridine - N - oxide contamination.
· Emergency Medicine: Forms the quaternary pyridinium backbone in pralidoxime chloride synthesis through nucleophilic addition. The product's precise isomeric purity (>99.9% 3 - isomer) ensures rapid oxime formation for organophosphate poisoning reversal.
· Antiviral Frontier: Emerging HIV - 1 protease inhibitor prototypes leverage 3 - PYR for heterocyclic ring closure. Recent pilot studies demonstrate its utility in creating symmetric dihydropyridine scaffolds that dock with mutant protease active sites, with two client molecules entering Phase I trials in 2024.
Enables production of next - generation acaricides targeting tetradifon - resistant mite populations. The aldehyde moiety participates in Knoevenagel condensation to form pyridyl - acrylate esters, yielding compounds with 40% lower aquatic toxicity compared to legacy products.
Facilitates synthesis of cyan - dye forming couplers in color reversal films. The nitrogen heterocycle provides ideal electron - withdrawing characteristics for azomethine dye formation, delivering enhanced spectral sensitivity in ISO 400+ emulsions.
· Research Quantities: 100g/500g amber borosilicate bottles with PTFE - lined caps, under argon blanket
· Bulk Shipments: 25kg UN - certified fluorinated HDPE drums with double - sealing and desiccant packs
· UN Number: UN3335 (Aviation regulated solid, n.o.s.)
· Hazard Class: 9 (Miscellaneous)
· Packing Group: III
· Temperature Control: Ambient (15 - 25°C); avoid exposure >40°C
· Moisture Sensitivity: Protect from humidity; maintain <30% RH during handling
Air/sea freight compliant with IATA/IMDG regulations; REACH - registered for EU entry; pre - cleared customs documentation for US/Canada/Asia - Pacific markets.
"After switching to this pharmaceutical - grade 3 - pyridinecarboxaldehyde, our bisacodyl synthesis saw a dramatic reduction in side - chain impurities from 2.3% to 0.4%. The supplier's certificate of origin simplified our FDA audit process significantly."
— Dr. L. Martinez, Process Chemistry Lead, Generic API Manufacturer (Spain)
"The stable supply during the 2023 raw material crisis was a lifesaver. Their dual - facility model meant we maintained 100% production uptime for our acaricide intermediate, while competitors faced 6 - week delays."
— J. Chen, Procurement Director, Crop Science Co. (China)
"For our HIV inhibitor research, the ultra - high purity allowed us to skip chromatographic purification steps entirely. Direct recrystallization gave us clean product—saved weeks of development time."
— Prof. R. K. Singh, Medicinal Chemistry Lab, NIH - Funded Research Institute (USA)
"Technical support team provided customized stabilization protocols for our tropical climate storage. No other vendor offered this level of post - sale engineering support."
— M. Fernandez, Operations Manager, Latin American Fine Chemicals Distributor
· cGMP Manufactured: ISO 9001:2015 certified facilities with FDA inspection readiness
· Analytical Excellence: Every batch undergoes NMR, GC - MS, and HPLC - ELSD characterization
· Stability Program: Real - time and accelerated studies per ICH Q1A(R2) available upon NDA
· Sustainability: 85% atom economy in synthesis; waste stream valorization reduces environmental footprint by 40% versus
